Standard Treatment Therapy depends primarily on the age of the patient and the grade of the cancer.
For borderline, well-differentiated tumors (Grade 1) in women who want to preserve their reproductive function, standard therapy includes removal of the cancerous ovary and the adjacent fallopian tube, partial removal of the omentum and other staging procedures determined by what is seen during surgery.
For postmenopausal women and those who do not want to preserve their reproductive function, standard therapy includes a total hysterectomy , removal of both fallopian tubes and ovaries and careful surgical staging. Women with Stage Ia borderline or Grade 1 carcinoma are usually cured with surgery alone.
Standard therapy for Grade 2 or 3 tumors is total hysterectomy, removal of both tubes and both ovaries, meticulous surgical staging and six monthly cycles of combination chemotherapy , usually with cisplatin or carboplatin + cyclophosphamide or cisplatin + Taxol . Other therapies that are sometimes recommended include total abdominal and pelvic radiation.
Investigational
• A Gynecologic Oncology Group trial is comparing intra-abdominal radioactive phosphate given once with
giving six cycles (once every three weeks) of intravenous cisplatin + cyclophosphamide for women with
poorly differentiated (Grades 2-3) tumors.
• Intra-abdominal chemotherapy with agents such as cisplatin or carboplatin or etoposide .
